Omeprazole.

lopidogrel is a prodrug activated in the liver to a metablite that is a specific and irreversible inhibitor of the platelet 2Y12 receptor. The P2Y12 receptor mediates the amplifiation of aggregation induced by adenosine diphosphate ADP) and also other agonists. In addition, P2Y12 inhibiion also affects coagulation and inflammation (1). These echanisms serve as the rationale for P2Y12 blockade in igh-risk cardiovascular disease. Indeed, following signifiant clinical benefits reported in major clinical trials, clopiogrel, along with aspirin therapy, is now widely used round the world to prevent thrombotic events in patients ith acute coronary syndromes and after coronary artery tenting (2).